Inhibition of Notch signaling by Dll4-Fc promotes reperfusion of acutely ischemic tissues

► Low dose Dll4-Fc increases vascular proliferation and overall perfusion. ► Low dose Dll4-Fc helps vascular injury recovery in hindlimb ischemia model. ► Low dose Dll4-Fc helps vascular injury recovery in skin flap model. ► Dll4 heterozygous deletion promotes vascular injury recovery. ► Dll4 overexpression delays vascular injury recovery.