Contribution of glucocorticoid-mineralocorticoid receptor pathway on the obesity-related adipocyte dysfunction

► Glucocorticoids induced adipocytokine dysregulation and ROS in adipocytes. ► Such changes were rectified by MR blockade, not by GR antagonist. ► In human, adipose MR was increased in parallel with body mass index. ► Glucocorticoid-MR pathway may contribute to the obesity-related disorders.