Selection and characterization of human antibody fragments specific for psoriasin - A cancer associated protein

► Psoriasin (S100A7) is a cancer biomarker that overexpression is associated with the tumor invasion and poor prognosis. ► Antibody phage display technology was applied to obtain binders specific for psoriasin. ► High affinity scFvs fragments were selected and characterized. ► Bivalent format of antibody fragment proved to interact with psoriasin in the cellular model. ► Described scFv is the first human antibody fragment specific for S100A7 obtained through phage display technology.