Astragalin attenuates lipopolysaccharide-induced inflammatory responses by down-regulating NF-κB signaling pathway

► Pretreatment with astragalin improved survival during lethal endotoxemia. ► Astragalin attenuated lung inflammatory responses elicited by lipopolysaccharide. ► Astragalin reduced cytokine levels, such as TNF-α, IL-1β and IL-6. ► Astragalin prevented the lipopolysaccharide-induced NF-κB activation.