Determination of osteogenic or adipogenic lineages in muscle-derived stem cells (MDSCs) by a collagen-binding peptide (CBP) derived from bone sialoprotein (BSP)

► CBP sequence is identified from BSP and has collagen binding activity. ► CBP directly activates the MAPK signaling, especially ERK1/2. ► CBP increase osteoblastic differentiation by the activation of Runx2. ► CBP decrease adipogenic differentiation by the inhibition of PPARγ.