The transcription factor FOXM1c is activated by protein kinase CK2, protein kinase A (PKA), c-Src and Raf-1

► The auto-inhibitory N-terminus of FOXM1c inhibits the transactivation domain of FOXM1c. ► Protein kinase CK2 activates FOXM1c by releasing FOXM1c from the inhibition by its N-terminus. ► Protein kinase A (PKA) activates FOXM1c by releasing FOXM1c from the inhibition by its N-terminus. ► c-Src activates FOXM1c by relieving the repression of FOXM1c by its auto-inhibitory N-terminus. ► Raf-1 activates FOXM1c independently of the auto-inhibitory N-terminus of FOXM1c.