Methionine sulfoxide reductase B in the endoplasmic reticulum is critical for stress resistance and aging in Drosophila

► Overexpression of MsrB in the ER increases resistance to oxidative stress. ► The ER-targeted MsrB expression enhances cold and heat tolerance. ► The ER-type MsrB expression extends lifespan and delays the age-related phenotypes. ► MsrB in the ER plays a critical role in stress resistance and aging in Drosophila.