Inhibition of JNK/dFOXO pathway and caspases rescues neurological impairments in Drosophila Alzheimer's disease model

► Aβ42 expression induces apoptosis and reduces survival and locomotion in Drosophila. ► Inhibition of JNK signaling or caspases suppresses the Aβ42-induced impairments. ► Aβ42-induced cell death and neurological phenotypes are dependent on the dFOXO level. ► Oral uptake of the JNK inhibitor rescues the impairments of Aβ42-expressing flies. ► JNK/dFOXO signaling is a major pathway mediating the impairments of the fly AD model.