TRAF6 inhibits proangiogenic signals in endothelial cells and regulates the expression of vascular endothelial growth factor

► TNF-receptor associated factors (TRAFs) function in the angiogenesis response. ► TRAF6 regulates basal and inducible expression of VEGF in endothelial cells (EC). ► TRAF6 is an endogenous inhibitor of EC proliferation and migration in EC. ► TRAF6 inhibits VEGF expression in part via its ability to regulate Src signaling.