Compensatory increase in lipogenic gene expression in adipose tissue of transgenic mice expressing constitutively active AMP-activated protein kinase-alpha1 in liver

► A line of transgenic mice is established to express constitutively active AMPK-α1 in liver. ► Activation of AMPK in liver causes marked compensatory increase in lipogenesis in adipose tissue. ► Adipose tissue plays an adaptive role in fat synthesis when the synthesis is reduced in liver.