Specific expression of the human voltage-gated proton channel Hv1 in highly metastatic breast cancer cells, promotes tumor progression and metastasis

► Hv1 is specifically expressed in highly metastatic human breast tumor tissues. ► Hv1 regulates breast cancer cytosolic pH. ► Hv1 acidifies extracellular milieu. ► Hv1 exacerbates the migratory ability of metastatic cells.