HIV-1 envelope protein gp120 up regulates CCL5 production in astrocytes which can be circumvented by inhibitors of NF-κB pathway

► In this study we studied effect of HIV gp120 on CCL5 production in astrocytes. ► Gp120 up-regulated CCL5 production in astrocytes. ► The increased CCL5 production could be partially abrogated by NF-κB specific inhibitor and siRNA. ► Gp120 mediated CCL5 increase could be interpreted only as mediator of inflammation.