Transcriptional activation of pig Galβ1,3GalNAc α2,3-sialyltransferase (pST3Gal I) gene by TGF-β1 in porcine kidney PK-15 cells

► mRNA levels of pST3Gal I are increased in PK-15 cells induced by TGF-β1. ► TGF-β1 treatment increases the level of glycan structure synthesized by pST3Gal I. ► Smad-3 site is crucial for transcriptional activation of pST3Gal I by TGF-β1.