Nandrolone reduces activation of Notch signaling in denervated muscle associated with increased Numb expression

► Nerve transection increased Notch signaling in paralyzed muscle. ► Nandrolone prevented denervation-induced Notch signaling. ► Nandrolone induced the expression of an inhibitor of the Notch signaling, Numb. ► Reduction of denervation-induced Notch signaling by nandrolone is likely through upregulation of Numb.