MicroRNA-binding is required for recruitment of human Argonaute 2 to stress granules and P-bodies

► Role of Argonaute domains in its intracellular localization. ► Ability to bind small RNA is required for localization of hAgo2 to RNA granules. ► Slicer activity is not required for targeting hAgo2 to stress granules. ► Loading of small RNAs onto hAgo2 is not required for its stability.