AICAR reverses ketone body mediated insulin resistance in isolated oxidative muscle

► β-Hydroxybutyrate inhibits insulin-mediated glucose uptake in oxidative muscle. ► We examined if AICAR, an activator of AMPK, reverses insulin resistance. ► AICAR restores most of the insulin effect on glucose uptake. ► AICAR exerts its positive effect on a late step in insulin signaling. ► Thus activation of AMPK reverses ketone-body mediated insulin resistance.