Anti-inflammatory effect of transduced PEP-1-heme oxygenase-1 in Raw 264.7 cells and a mouse edema model

► Recombinant PEP-1 heme oxygenase-1 expression vector was constructed and overexpressed. ► We investigated transduction efficiency of PEP-1-HO-1 protein in Raw 264.7 cells. ► PEP-1-HO-1 was efficiently transduced into Raw 264.7 cells in a dose and time dependent manner. ► PEP-1-HO-1 exerted anti-inflammatory activity in Raw 264.7 cells and in a mice edema model. ► PEP-1-HO-1 could be used as a therapeutic drug against inflammatory diseases.