Oxidized low-density lipoprotein-induced periodontal inflammation is associated with the up-regulation of cyclooxygenase-2 and microsomal prostaglandin synthase 1 in human gingival epithelial cells

► OxLDL-induced responses in human gingival epithelial cells were studied. ► OxLDL enhanced the production of IL-8, IL-1β and PGE2 in Ca9-22 cells. ► An NF-κB inhibitor suppressed the expression of COX-2 and mPGES1 induced by oxLDL. ► Unlike the case in macrophages, oxLDL did not increase the CD36 level.