Levels of histone acetylation in thyroid tumors

► H3K9-K14 acetylation is higher in thyroid tumors than in normal thyroid tissue. ► H4K12 acetylation is higher in thyroid adenoma than in thyroid carcinoma. ► Oncoproteins RET-PTC, RAS and BRAF increase levels of H3K9-K14 and H3K18 acetylation. ► In the rat thyroid cell line FRTL-5, TSH controls levels of histone acetylation.