Characterization of ADAM28 as a biomarker of bladder transitional cell carcinomas by urinary proteome analysis

► The aim of this study is to utilize proteomic approach to establish urinary protein patterns of bladder cancer. ► In this study, the arsenic concentrations in the urine of bladder cancer patients were still significantly higher than control group. ► Search for new biomarkers for the early detection, monitoring, and prognosis of bladder cancer is an active area of interest. ► The ADAM28 was confirmed by Western blotting and may be treated as possible biomarker of bladder cancer.