Glutathione selectively inhibits Doxorubicin induced phosphorylation of p53Ser15, caspase dependent ceramide production and apoptosis in human leukemic cells

► GSH influences the clinical efficacy of Doxorubicin in human leukemic cells. ► GSH inhibits the of Doxorubicin-induced p53Ser15 phosphorylation. ► GSH also selectively inhibits Doxorubicin-induced caspase dependant Cer generation and apoptosis.