Generation of mice deficient in RNA-binding motif protein 3 (RBM3) and characterization of its role in innate immune responses and cell growth

► We identified RNA-binding motif protein 3 (RBM3) as CpG-B DNA-binding protein. ► RBM3 translocates from the nucleus to the cytoplasm and co-localized with CpG-B DNA. ► We newly generated Rbm3-deficient (Rbm3-/-) mice. ► DNA-mediated cytokine gene induction was normally occured in Rbm3-/- cells. ►Rbm3-/- MEFs showed poorer proliferation rate and increased number of G2-phase cells.