Identification of a novel function for the FtsL cell division protein from Escherichia coli K12

► FtsL is shown to have a novel function, the generation of Zn(II)-sensitivity. ► Specific residues within the primary sequence identified as associated with Zn(II)-ion sensitivity. ► Mutated FtsL derivatives capable of supporting cell-division. ► Loss of a cysteine-pair in FtsL results in sensitivity to elevated Zn(II).