Perturbations of model membranes induced by pathogenic dynorphin A mutants causing neurodegeneration in human brain

► Dynorphin A neuropeptides cause leakage in model membranes. ► Model membranes are unilamellar phospholipid vesicles with encapsulated calcein. ► Degree of leakage varies for dynorphin A mutants R6W, R9C and L5S. ► Vesicle leakage correlates with neurotoxicity of dynorphin A mutants.