Inhibition of melanogenesis by 5,7-dihydroxyflavone (chrysin) via blocking adenylyl cyclase activity

► The signal transduction induced by adenylyl cyclase activity can be down-regulated by anti-oxidant, chrysin. ► Chrysin showed a potent anti-melanogenic effects via blocking adenylyl cyclase activity. ► Targeting adenylyl cyclase may also have a great potential to regulate cyclic nucleotide signal in melanogenesis.