Hyal2 is a glycosylphosphatidylinositol-anchored, lipid raft-associated hyaluronidase

► Hyal2 is one of two somatic hyaluronidases with demonstrated enzymatic activity. ► We used MDA-MB231 cancer cells with high expression of Hyal2 and transfected COS cells. ► We show that Hyal2 is strongly linked to cell membranes through a GPI anchor. ► Hyal2 belongs to lipid rafts, like CD44.