Evaluation of anti-depressant-like activity of linezolid, an oxazolidinone class derivative - An investigation using behavioral tests battery of depression

► Linezolid, the first marketed oxazolidinone antibiotic is a MAO-A inhibitor. ► MAO-A enzyme regulates the catabolism of monoamine neurotransmitters in the brain. ► Depression is associated with functional deficiency of catecholamine neurotransmitters in synaptic cleft. ► Linezolid showed anti-depressant-like effect in rodent's behavioral model.