Electrogenic Na+/HCO3- co-transporter-1 is essential for the parathyroid hormone-stimulated intestinal HCO3- secretion

► NBCe1 knockdown was performed by three siRNA sequences against variants 1-3 of NBCe1. ► PTH-stimulated HCO3- secretion was diminished in NBCe1 knockdown Caco-2 monolayer. ► Fluid secretion was rapidly enhanced in the rat ileum after intravenous PTH infusion.