Osteoblast-enriched membrane protein IFITM5 regulates the association of CD9 with an FKBP11-CD81-FPRP complex and stimulates expression of interferon-induced genes

► Interferon-inducible transmembrane protein 5 (IFITM5) directly interacts with FKBP11 in osteoblasts. ► FKBP11 forms a complex with CD81-[FPRP/CD9]. ► IFITM5 expression dissociates CD9 from this complex and induces genes involved in immune system.