کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10763673 1050522 2011 7 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
IGF-1Ea induces vessel formation after injury and mediates bone marrow and heart cross-talk through the expression of specific cytokines
چکیده انگلیسی
► In skeletal muscle overexpression of IGF-1Ea mobilizes bone marrow stem cell favouring tissue repair and integrity. ► We observed that in cardiac muscle IGF-1Ea induces VEGF and MCP2 expression. ► Increased number of c-Kit/Sca1 positive cells in the bone marrow correlates with the cytokine profile. ► Moreover, cardiac side population is primed to form endothelial-like tubular structure by IGF-1Ea. ► The above signaling correlates with recapillarization of the cardiac tissue in the area bordering the infarct.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 410, Issue 2, 1 July 2011, Pages 201-207
نویسندگان
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