Glioma-derived mutations in isocitrate dehydrogenase 2 beneficial to traditional chemotherapy

► IDH1 and IDH2 mutations are not detected in the rat C6 glioma cell line model. ► IDH2 mutations are not required for the tumorigenesis of glioma. ► IDH2R172G can sensitize glioma sensitivity to chemotherapy through NADPH levels. ► IDH2R172G can give a benefit to traditional chemotherapy of glioma. ► This finding serves as an important complement to existing research on this topic.