Generation of a Slc39a8 hypomorph mouse: Markedly decreased ZIP8 Zn2+/(HCO3-)2 transporter expression

► The mouse Slc39a8 gene encodes the ZIP8 transporter. ► ZIP8 functions endogenously as a electroneutral Zn2+/(HCO3-)2 symporter. ► A Slc39a8(neo/neo) hypomorph mouse, due to retention of the neo mini-gene, has been created. ► ZIP8 expression in utero is ∼90% decreased in all tissues examined. ► This mouse model will be useful for studying developmental and in utero physiological functions of ZIP8.