Lipoxin A4 inhibits the production of proinflammatory cytokines induced by β-amyloid in vitro and in vivo

► Revealing unprecedented finding that LXA4 suppress the Aβ-stimulated inflammation. ► Observing the beneficial outcome of LXA4 on the Aβ-stimulated inflammation. ► Discussing the anti-inflammatory mechanisms of LXA4 in vitro and in vivo. ► Revealing that LXA4 inhibits IL-1β and TNFα stimulated by Aβ via the NF-κB. ► Discussing the potential therapeutic effect of LXA4 on the development of AD.