Fto colocalizes with a satiety mediator oxytocin in the brain and upregulates oxytocin gene expression

► The majority of neurons synthesizing a satiety mediator, oxytocin, coexpress Fto. ► The level of colocalization is similar in the male and female brain. ► Fto overexpression in hypothalamic neurons increases oxytocin mRNA levels by 50%. ► Oxytocin does not affect Fto expression through negative feedback mechanisms.