T-817MA, a neuroprotective agent, attenuates the motor and cognitive impairments associated with neuronal degeneration in P301L tau transgenic mice

► This study investigated the neuroprotective effect of T-817MA on tau-related disorders. ► Tau abnormalities are implicated in the pathogenesis of neurodegenerative tauopathies. ► T-817MA, a neuroprotective agent, inhibited the neuronal damages and improved behavioral impairment in the tau transgenic mice. ► T-817MA may have a therapeutic potential for tau-related neurodegenerative diseases such as Alzheimer's disease.