Cigarette smoke suppresses the ubiquitin-dependent degradation of OLC1

► Cigarette smoke increases OLC1 level with dose- and time-dependent manner. ► Cigarette smoke impaired OLC1 ubiquitination-mediated degradation. ► E3 ligase APC governs the degradation of OLC1. ► Cigarette smoke impaired the association of OLC1 to APC.