Activation of peroxisome proliferator-activated receptor-α enhances fatty acid oxidation in human adipocytes

► PPARα activation increased mRNA expression levels of adipocyte differentiation marker genes and GPDH activity in human adipocytes. ► PPARα activation also increased insulin-dependent glucose uptake in human adipocytes. ► PPARα activation did not affect lipid accumulation in human adipocytes. ► PPARα activation increased fatty acid oxidation through induction of fatty acid oxidation-related genes in human adipocytes.