Ghrelin inhibits proliferation and increases T-type Ca2+ channel expression in PC-3 human prostate carcinoma cells

► Ghrelin decreases prostate carcinoma PC-3 cells proliferation. ► Ghrelin favors apoptosis in PC-3 cells. ► Ghrelin increase in intracellular free Ca2+ levels in PC-3 cells. ► Grelin up-regulates expression of T-type Ca2+ channels in PC-3 cells. ► PC-3 cells express T-channels of the CaV3.1 and CaV3.2 subtype.