Efficient hydrolysis of the chemical warfare nerve agent tabun by recombinant and purified human and rabbit serum paraoxonase 1

► Reporting for the first time that paraoxonase 1 (PON1) efficiently hydrolyzes tabun. ► Efficiency of tabun hydrolysis by PON1 was compared to that of sarin and soman. ► Demonstrate that hydrolysis of the nerve agents is PON1 specific. ► Evaluated retention of PON1 activity and 3-fold more hydrolysis of nerve agents. ► PON1 can be used as a universal bioscavenger against nerve agents.