Intercellular transfer regulation of the paracrine activity of GPI-anchored Cripto-1 as a Nodal co-receptor

► Membrane-anchorage of Cripto-1 is required for its paracrine activity as a Nodal co-receptor. ► Cripto-1 can be intracellularly transferred as a membrane protein. ► Expression of Cripto-1 alters physiochemical property of plasma membrane and may enhance intercellular transfer of membrane components.