C-type lectins do not act as functional receptors for filovirus entry into cells

► Filovirus glycoprotein (GP) having a deficient receptor binding region were generated. ► Mutant GPs mediated virus entry less efficiently than wild-type GP. ► Mutant GPs bound to C-type lectins but not mediated entire steps of cellular entry. ► C-type lectins do not independently mediate filovirus entry into cells. ► Other molecule(s) are required for C-type lectin-mediated entry of filoviruses.