miR-132 and miR-212 are increased in pancreatic cancer and target the retinoblastoma tumor suppressor

► The expression of miR-132 and miR-212 are significantly increased in pancreatic cancer. ► miR-132 and miR-212 target the tumor suppressor pRb, resulting in enhanced proliferation. ► miR-132 and miR-212 expression is increased by a β2 adrenergic receptor agonist, suggesting a novel mechanism for pancreatic cancer progression.