Activation of calcium-sensing receptor increases TRPC3 expression in rat cardiomyocytes

► Calcium-sensing receptor (CaR) activation stimulates TRP channels. ► CaR promoted transient receptor potential C3 (TRPC3) expression. ► Adult rat ventricular myocytes display capacitative calcium entry (CCE), which was operated by TRPCs. ► TRPC channels activation induced by CaR activator sustained the increased [Ca2+]i to evoke cardiomyocytes apoptosis.