The essential role of FKBP38 in regulating phosphatase of regenerating liver 3 (PRL-3) protein stability

► FKBP38 interacts with PRL-3. ► FKBP38 promotes degradation of endogenous PRL-3 protein via protein-proteasome pathway. ► FKBP38 suppresses PRL-3 oncogenic function. ► FKBP38 is a novel negative regulator of the oncogenic protein PRL-3.