Glycosaminoglycans enhance the fibrillation propensity of the β2-microglobulin cleavage variant - ΔK58-β2m

► The de novo fibrillation of β2-microglobulin in dialysis related amyloidosis may involve the aggregation prone cleavage variant ΔK58-β2m. ► Glycosaminoglycans play a significant role for the consolidation of early ΔK58-β2m fibrils, thus enabling overt and irreversible fibrillation. ► The presence of heparan sulfate stabilizes the ΔK58-β2m fibrils and affect the morphology of these. ► The morphology of ΔK58-β2m fibrils clearly affects the ability of these to nucleate native β2m fibril formation.