کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10764305 1050539 2010 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی زیست شیمی
پیش نمایش صفحه اول مقاله
Inflammatory cytokines regulate microRNA-155 expression in human retinal pigment epithelial cells by activating JAK/STAT pathway
چکیده انگلیسی
► Combination of IFN-γ, TNF-α and IL-1β increased microRNA-155 expression in human retinal pigment epithelial cells. ► Two putative STAT1 binding elements are present in the MIR155 gene promoter region. ► Increase in miR-155 expression was associated with increase in STAT1 activation. ► Increase in miR-155 expression was associated with increase in protein binding to putative STAT1 binding elements. ► Increases in miR-155 expression, STAT1 activation and protein binding were blocked by JAK inhibitor 1.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Biochemical and Biophysical Research Communications - Volume 402, Issue 2, 12 November 2010, Pages 390-395
نویسندگان
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