Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress

► We performed comprehensive survey for proteins that bind to oxidized RNA. ► HNRNPD and HNRNPC proteins were identified as oxidized RNA binding proteins. ► Knockdown of HNRNPD/C expression caused increased sensitivity to H2O2. ► Amounts of HNRNPD protein rapidly decreased when cells were exposed to H2O2.