Universal antibodies against the highly conserved influenza fusion peptide cross-neutralize several subtypes of influenza A virus

► The fusion peptide is the only universally conserved epitope in all influenza viral hemagglutinins. ► Anti-fusion peptide antibodies are universal antibodies that cross-react with all influenza HA subtypes. ► The universal antibodies cross-neutralize different influenza A subtypes. ► The universal antibodies inhibit the fusion process between the viruses and the target cells.