Hydrogen sulfide as an effective and specific novel therapy for acute carbon monoxide poisoning

► Oxidative stress, neuronal apoptosis and necrosis occur over hours to days following carbon monoxide poisoning. ► Previous studies have shown that free radical scavengers can display neuroprotective properties. ► Hydrogen sulfide (H2S) could protects neurons against oxidative stress, attenuates lipopolysaccharides (LPS) induced neuroinflammation in microglia, exhibited anti-inflammatory and anti-apoptotic activities. ► We hypothesize that H2S might be an interesting potential strategy for curing acute carbon monoxide poisoning.