Intermedilysin induces EGR-1 expression through calcineurin/NFAT pathway in human cholangiocellular carcinoma cells

► ILY leads to the accumulation of [Ca2+]i in the nucleus in HuCCT1 cells. ► ILY induced activation of NFAT1 through a calcineurin-dependent pathway. ► Calcineuri/NFAT pathway is involved in EGR-1 expression in response to ILY treatment.